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Bismuth subsalicylate (Pepto-Bismol) contains two active ingredients- bismuth and salicylate (aspirin). Bismuth compounds are effective only in traveler’s diarrhea and the treatment of H.pylori. It is not clear how bismuth subsalicylate would work with the only exception of traveler diarrhea. It is like an antibiotic that affects bacteria causing diarrhea. Bismuth may lower the water secretion by the intestine and anti-inflammatory salicylate reduces the water secretion.
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